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Depression Home >> Antidepressants >> Clomipramine (Anafranil)

Clomipramine (Anafranil) Antidepressant

Clomipramine (Anafranil) is an antidepressant from the heterocyclic antidepressants family of drugs. This drug is used mainly in the treatment of OCD (obsessive-compulsive disorder), but is also used to relief symptoms of arm burning, endogenous depression, hair pulling syndromes, nail biting, panic attacks, phobias, or PMS. It is used in the treatment of narcolepsy and to relieve the pain of arthritis, cancer, diabetic disease, herpes lesions, migraines, tension headaches, or tic douloureux. It may also help decrease the repetitive symptoms in autistic persons.

CLASS: Tertiary Tricyclic.
Generic name: Clomipramine Hydrochloride..
Type: Antidepressant / Antiobsessional.

Strengths:

  • Capsules: 25 mg, 50 mg, 75 mg.

Dosages: Actual dosage must be determined by the physician.

Oral:
Start: 25mg in evening.
Increases: 25mg daily in intervals of 3 or 4 days until 100mg daily.
Maintenance: 50mg to 150mg in 24 hours.
Maximum: 250mg in 24 hours.

Normal dosage:

If under 10 years of age, DO NOT USE!
10 to 60 years of age, 25 mg to 100 mg.
Over 60 years of age, Lower doses increased cautiously.

Problems with:

Liver Function: Lower dosage, as needed.
Kidney Function: Not usually needed.

Test:

Before taking: N/A
While taking: N/A

Take With: Taken after meals.

Full Benefits In: In a few days to a few weeks. If any unpleasant side effects, they should appear right away.

Missed Dose(s): If you take this drug at bedtime and miss it do not take in morning. If within one hour take, if over an hour skip and then continue on your normal schedule.
Never Take a Double Dose!

If Stop Taking: Do not stop without consulting your physician and never abruptly.

Overdose symptoms include: Agitation, coma, confusion, convulsions, delirium, fever, hallucinations, shallow breathing, shock, seizures, or tremors.
Can Be Fatal!

Warnings

  • The habit-forming potential is none. This drug if beneficial should be taken about six months, in a few up to a year.
  • Do not drink alcohol while taking this drug.
  • Do not take this drug if you are pregnant, try some non-drug alternatives.
  • Do not take this drug if planning to become pregnant. Do not take if you are breast-feeding.
  • Do not take this drug if you have taken any monoamine oxidase ( MAO ) in the past two weeks. If you have narrow-angle glaucoma, if you have had a recent heart attack, any blood cell disorders, or active bone marrow depression.
  • Do not give this drug to children under ten and in lower doses to adolescents. If over sixty only use drug in small doses and with close monitoring of it's side effects. The elderly should be careful when standing, the blood pressure lowering effects of this drug may make them fall.

Do not use if: You had negative reactions to this drug or any drug in this class in the past.

Inform your Doctor if: You had negative reactions to this drug or any drug in this class in the past. If you have epilepsy. If you are taking any other prescription or non-prescription drug. If you plan to be under anesthesia or having any surgery in the next few months, also if you will be under-going any medical tests.

Clomipramine (Anafranil) Side Effects

Common: Blurred vision, constipation, drowsiness, dry mouth, low blood pressure, nausea, or vomiting.

Rare: Allergies, confusion, increased appetite, insomnia, racing heartbeat / palpitations, skin rashes, seizures, or sexual problems.

See physician always: Allergies, confusion, low blood pressure, skin rashes, seizures, sexual problems, or vomiting.

See physician if severe: Blurred vision, constipation, drowsiness, dry mouth, increased appetite, insomnia, nausea, or racing heartbeat / palpitations.

See physician NOW: Allergies, confusion,or skin rashes.

Stop taking and see physician NOW: Seizures.
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If you suffer from depression, you could talk to your doctor about trying the ST JOHNS WORT herbal remedy – it’s a great antidepressant used by millions worldwide.
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Whenever someone sorrows, I do not say, 'forget it,' or 'it will pass,' or 'it could be worse' -- all of which deny the integrity of the painful experience. But I say, to the contrary, 'It is worse than you may allow yourself to think. Delve into the depth. Stay with the feeling. Think of it as a precious source of knowledge and guidance. Then and only then will you be ready to face it and be transformed in the process. - Peter Koestenbaum
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